Endocervical disease is treated by deep excision.

In the case of a transformation zone of type 3, the squamo-columnar junction is not visible. Accordingly, the extent of the lesion (highlighted in green) cannot be seen.

Given the morphological characteristics above, with a lesion located in the endocervical canal, CO₂ laser conization or multiple-step loop excision are feasible. If a specimen with small base and long axis is required to be assessed by pathology, laser conization is feasible. If the surgeon opts for loop excision, multiple specimens have to be sent for histopathologic evaluation. The pathologist must be given a record allowing for exact topographic allocation of each specimen. Endocervicoscopy with a small diameter hysteroscope can be helpful to locate the lesion and determine its endocervical extent. Based on these findings, the anticipated depth of excision can be defined.