Secondary Prevention of Cervical Cancer

Ridge Sign, Rag Sign and Inner Border Sign

Prevalence of 3 Pathognomonic Colposcopic Criteria in 335 Women with Atypical Transformation Zone Correlated with Histological Diagnosis

	Ridge Sign (n)	Inner Border Sign (n)	Rag Sign (n)
No CIN	2 (1.6%)	1 (2.1%)	4 (4.3%)
LSIL	2 (1.6%)	0	0
HSIL (AIS)	122 (1)	47 (98%)	90 (96%)
Total	127	48	94

CIN (Cervical Intraepithelial Neoplasia), SIL (Squamous Intraepithelail Lesion), H (high-grade), L (low-grade), AIS (Adenocarcinoma-in-situ).

Ridge Sign, Rag Sign and Inner Border Sign

Prevalence of 3 Pathognomonic Colposcopic Criteria in 335 Women with Atypical Transformation Zone Correlated with Histological Diagnosis

	Ridge Sign (n)	Inner Border Sign (n)	Rag Sign (n)
No CIN	2 (1.6%)	1 (2.1%)	4 (4.3%)
LSIL	2 (1.6%)	0	0
HSIL (AIS)	122 (1)	47 (98%)	90 (96%)
Total	127	48	94

CIN (Cervical Intraepithelial Neoplasia), SIL (Squamous Intraepithelail Lesion), H (high-grade), L (low-grade), AIS (Adenocarcinoma-in-situ).

Ridge Sign, Inner Border Sign and Rag Sign are caused by HSIL.

In a survey comparing the three pathognomonic criteria, the highest prevalence is found for ‘ridge sign’, followed by ‘rag sign’ and ‘inner border sign’ in this cohort of patients. The correlation of each of the three pathognomonic signs with HSIL is highly significant (p < 0.001).