Secondary Prevention of Cervical Cancer

Zones and Junctions – Definitions

Transformation-Zone and Junctions

  • Junction = border
  • Transformation zone (T-zone) = area
  • Until puberty, congenital junction is present
  • Post puberty, the adult (= functional) junction is formed
  • T-zone becomes larger with age
  • Initially, the T-zone is made of metaplastic epithelium
  • Metaplastic epithelium transforms into squamous epithelium
  • Adult (= functional) junction can be visualized histopathologically
  • Congenital junction cannot be visualized histopathologically post puberty

Zones and Junctions – Definitions

Transformation-Zone and Junctions

  • Junction = border
  • Transormation zone (T-zone) = area
  • Until puberty, congenital junction is present
  • Post puberty, the adult (= functional) junction is formed
  • T-zone becomes larger with age
  • Initially, the T-zone is made of metaplastic epithelium
  • Metaplastic epithelium transforms into squamous epithelium
  • Adult (= functional) junction can be visualized histopathologically
  • Congenital junction cannot be visualized histopathologically post puberty

Zones are areas, junctions are lines.

Junction is a term used to define the border between different epithelia, whereas T-zone describes the area between junctions.

The original squamocolumnar junction between squamous and columnar epithelium remains unchanged till puberty and is called the congenital junction.

During and post puberty, in addition to the congenital junction, the adult or functional junction is formed, subsequently termed the new squamocolumnar junction.

The T-zone becomes larger with age and expands centrally towards the cervical opening.

Initially, the T-zone is made of metaplastic epithelium, which changes to secondary squamous epithelium. Secondary squamous epithelium cannot be distinguished by histopathology from primary squamous epithelium.

The adult or functional junction can always be identified by histopathology wheras the congenital junction cannot be seen using this diagnostic modality post puberty. Colposcopically, the location of the congenital junction can be guessed by the extension of Ovula Nabothi, open crypts (glands) or metaplastic epithelium.