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Photodynamic Diagnostics (PDD) of Carcinomata of the Bladder
In 1995, KARL STORZ achieved a milestone in urology with the market launch of the PDD system for the early detection of urinary bladder carcinoma. All European pre-approval studies with Hexvix® exclusively used the PDD system developed by KARL STORZ. In 2010, this system was also approved for the US market by the FDA.
The KARL STORZ PDD system is now the most frequently used system for photodynamic diagnostics of urinary bladder carcinoma in Germany and Europe. It consists of several perfectly compatible components: The high-power light source (D-Light C) in combination with a corresponding fluid light cable, special endoscopes, and a 3-chip endocamera that represents the newest KARL STORZ development in this area and is characterized by particularly high light sensitivity and very good color contrast when compared with other 1-chip and even 3-chip camera systems on the market.
The KARL STORZ PDD system is now the most frequently used system for photodynamic diagnostics of urinary bladder carcinoma in Germany and Europe. It consists of several perfectly compatible components: The high-power light source (D-Light C) in combination with a corresponding fluid light cable, special endoscopes, and a 3-chip endocamera that represents the newest KARL STORZ development in this area and is characterized by particularly high light sensitivity and very good color contrast when compared with other 1-chip and even 3-chip camera systems on the market.
The importance of photodynamic diagnostics is supported by publications on two recently completed clinical studies. In the first study, the PDD mode identified residual tumors in 44% of patients after white light TURB had been completed [1].
After 12 months, the recurrence rate was 47.3% in the white light group and 30.5% in the PDD group (p=0.02). In the second study, the use of fluorescence diagnostics increased the detection rate of bladder tumors by 16% [2].
[1] Gregers H. Hermann et al. Fluorescence-guided transurethral resection of bladder tumours reduces bladder tumour recurrence due to less residual tumour tissue in Ta/T1 patients: a randomized two-centre study. BJU 2011
[2] Arnulf Stenzel et al.Hexaminolevulinate Guided Fluorescence Cystoscopy Reduces Recurrence in Patients with Nonmuscule Invasive Bladder Cancer. J Urol 2010 (184), 1907-1914.
After 12 months, the recurrence rate was 47.3% in the white light group and 30.5% in the PDD group (p=0.02). In the second study, the use of fluorescence diagnostics increased the detection rate of bladder tumors by 16% [2].
[1] Gregers H. Hermann et al. Fluorescence-guided transurethral resection of bladder tumours reduces bladder tumour recurrence due to less residual tumour tissue in Ta/T1 patients: a randomized two-centre study. BJU 2011
[2] Arnulf Stenzel et al.Hexaminolevulinate Guided Fluorescence Cystoscopy Reduces Recurrence in Patients with Nonmuscule Invasive Bladder Cancer. J Urol 2010 (184), 1907-1914.